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Central nervous system
Central nervous system


Definition:

Gram-negative meningitis is an infection of the membranes covering the brain and spinal cord (meninges) caused by bacteria that turn pink when exposed to a special stain (gram-negative bacteria).

See also:



Alternative Names:

Gram-negative meningitis



Causes, incidence, and risk factors:

Acute bacterial meningitis can be caused by gram-negative bacteria. Bacteria causing gram-negative meningitis include:

  • Acinetobacter baumannii
  • Enterobacter aerogenes
  • Escherichia coli
  • Klebsiella pneumoniae
  • Pseudomonas aeruginosa

Gram-negative meningitis is much more common in infants than adults.

Risk factors in adults and children include:



Symptoms:

Signs and tests:

A physical examination may show:

For any patient with meningitis, it is important to perform a lumbar puncture ("spinal tap "), in which spinal fluid (known as cerebrospinal fluid, or CSF) is collected for testing.

Tests include:



Treatment:

Antibiotic treatment through a vein (IV) usually starts right away. If you have a shunt, it may be removed to get rid of the infection.



Support Groups:



Expectations (prognosis):

It is important to recognize the symptoms of this meningitis, and seek treatment as soon as possible. Early treatment may prevent serious illness or death.

Many people recover completely, but a large number of people have permanent brain damage or die from this type of meningitis. Between 40% and 80% of patients with gram-negative meningitis do not survive, although these numbers may be improving. The likelihood of survival depends on:

  • How quickly the infection is treated
  • Other medical conditions that may be present
  • The patient's age


Complications:

Calling your health care provider:

Go to the emergency room or call the local emergency number (such as 911) if you notice symptoms of meningitis. This condition can be very serious and needs immediate treatment.



Prevention:

Prompt treatment of related infections may reduce the risk of meningitis.



References:

Swartz MN. Meningitis: bacterial, viral, and other. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 437.




Review Date: 9/28/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Jatin M. Vyas, PhD, MD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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