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Blood cells
Blood cells


Definition:

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that causes blood clots to form in small blood vessels around the body, and leads to a low platelet count (thrombocytopenia ).

See also: Hemolytic-uremic syndrome



Alternative Names:

TTP



Causes, incidence, and risk factors:

This disease may be caused by the lack of an enzyme (a type of protein) that is involved in blood clotting. Not having enough of this enzyme causes clotting to occur. As the platelets clump together in these clots, fewer platelets are available in the blood in other parts of the body to help with clotting. This can lead to bleeding under the skin and purple-colored spots called purpura .

In many cases, the disorder is passed down through families (inherited). The condition also may be related to:



Symptoms:

Signs and tests:

Treatment:

Plasma exchange (plasmapheresis) is used to remove the abnormal antibody from the blood and replace the missing enzyme.

First, you will have your blood drawn as if you were donating blood.The plasma portion of the blood will be passed through a cell separator. The remaining portion of the blood will be saved. Plasma will be added to it, and the blood will be returned to you through a transfusion.

This treatment is repeated daily until blood tests show improvement. People who do not respond to this treatment, or who have frequent recurrences, may need to have surgery to remove their spleen. Or, they may need to get drugs that suppress the immune system (such as corticosteroids).



Support Groups:



Expectations (prognosis):

Plasma exchange has improved the outcome of this disease. Most patients now recover completely. However, some people can die from this disease, especially if it is not found immediately. In people who don't recover, this condition can become long-term (chronic ).



Complications:
  • Kidney failure
  • Low platelet count (thrombocytopenia)
  • Low red blood cell count (caused by the premature breakdown of red blood cells)
  • Nervous system problems
  • Severe bleeding (hemorrhage)
  • Stroke


Calling your health care provider:

Call your health care provider if you have any unexplained bleeding.



Prevention:

Because the cause is unknown, there is no known way to prevent this condition.



References:

Schafer A. Hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa:Saunders Elsevier;2007:chap 179.




Review Date: 3/2/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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