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Endocrine glands
Endocrine glands


The pituitary gland
The pituitary gland


Pituitary hormones
Pituitary hormones


Definition:

Hypogonadotropic hypogonadism is absent or decreased function of the male testes or the female ovaries. It is considered a form of secondary hypogonadism, which means the condition is due to a problem with the pituitary or hypothalamus gland.

See also: Hypogonadism



Alternative Names:

Gonadotropin deficiency; Secondary hypogonadism; Kallmann syndrome



Causes, incidence, and risk factors:

Hypogonadotropic hypogonadism results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH).

Normally, the hypothalamus in the brain releases gonadotropin-releasing hormone (GnRH), which stimulates the pituitary gland to release other hormones, including FSH and LH. These hormones tell the female ovaries and male testes to secrete hormones that are responsible for normal sexual development in puberty. A disruption in this chain of events causes a deficiency of the sex hormones and halts normal sexual maturation.

Failure of the hypothalamus is most commonly a result of Kallmann syndrome. Kallmann syndrome is an inherited form of hypogonadotropic hypogonadism that usually involves a disorder with the sense of smell.



Symptoms:
  • Absence of secondary sexual characteristics such as pubic, facial, and underarm hair
  • Inability to smell (in some cases)
  • Lack of development at puberty (may involve incomplete development or a significant delay in development)
  • Underdeveloped testicles
  • Short stature (in some cases)


Signs and tests:

Tests that may be done include:



Treatment:

Treatment depends on the source of the problem but may involve:

  • Injections of testosterone
  • Slow-release testosterone skin patch
  • Estrogen and progesterone pills
  • GnRH injections


Support Groups:



Expectations (prognosis):

With proper hormonal stimulation, puberty can occur and fertility may be restored.



Complications:
  • Delayed puberty
  • Infertility
  • Low self-esteem due to late onset of puberty; emotional support may be helpful


Calling your health care provider:

Call your health care provider if your child does not enter puberty as expected.



Prevention:

Prevention depends on the cause. Genetic counseling may be appropriate for individuals with a family history of inherited disorders associated with hypogonadism. Prevention of serious head injuries reduces the risk of pituitary injury-associated hypogonadotropic hypogonadism.



References:

AACE Thyroid Task Force. AACE Hypogonadism Guidelines. Endocr Pract. 2002;8(6):441.




Review Date: 10/24/2007
Reviewed By: Robert Hurd, MD, Professor of Endocrinology, Department of Biology, Xavier University, Cincinnati, OH, and physician in the Primary Care Clinic, Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio. Review provided by VeriMed Healthcare Network.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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