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Pancreas
Pancreas


Definition:

VIPoma is a very rare type of cancer that usually grows from certain cells in the pancreas.



Alternative Names:

Vasoactive intestinal peptide-producing tumor; Pancreatic endocrine tumor



Causes, incidence, and risk factors:

VIPoma causes cells in the pancreas to produce high levels of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines and relaxes some of the smooth muscles in the GI system.

The cause is not known.

VIPomas are usually diagnosed in adults, most commonly at age 50. Women are more likely to be affected than men. This cancer is rare, affecting an estimated 1 in 10 million people per year.



Symptoms:
  • Abdominal pain and cramping
  • Flushing or redness of the face
  • Nausea
  • Watery diarrhea (often massive amounts)
  • Weight loss


Signs and tests:

Signs may include:

  • Dehydration
  • High volume of diarrhea (even without eating)
  • Low stomach acid (achlorhydria)
  • Low blood potassium (hypokalemia ), which can cause leg cramps

Tests include:

  • CT scan
  • MRI
  • Stool examination for cause of diarrhea and electrolyte levels
  • Vasoactive intestinal peptide (VIP) in the blood


Treatment:

The first goal of treatment is to correct dehydration. Fluids are often given through a vein (intravenous fluids) to replace fluids lost in diarrhea.

The next goal is to slow the diarrhea. Some medications can help control diarrhea. Ocreotide, which is a man-made form of a natural hormone, blocks the action of VIP.

The best chance for a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure it.



Support Groups:



Expectations (prognosis):

Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumors have spread by the time of diagnosis and are not curable.



Complications:
  • Cancer spread (metastasis)
  • Cardiac arrest from electrolyte imbalances
  • Dehydration


Calling your health care provider:

If you have watery diarrhea for more than 2-3 days, call your doctor.



Prevention:



References:

Jensen RT, Norton JA. Endocrine tumors of the pancreas and gastrointestinal tract. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2006:chap 31.




Review Date: 9/4/2008
Reviewed By: Sean O. Stitham, MD, private practice in Internal Medicine, Seattle, Washington; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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