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Vasculitis on the palm
Vasculitis on the palm


Vasculitis
Vasculitis


Vasculitis, urticarial on the hand
Vasculitis, urticarial on the hand


Definition:

Allergic vasculitis is an extreme reaction to a drug, infection, or foreign substance that leads to inflammation and damage to blood vessels of the skin.



Alternative Names:

Vasculitis - allergic; Hypersensitivity vasculitis; Cutaneous leukocytoclastic vasculitis



Causes, incidence, and risk factors:

Allergic vasculitis is caused by an allergic reaction to a drug or other foreign substance. Most patients are older than 15 years.

Even with a thorough history, the cause of this condition cannot be identified.



Symptoms:
  • Purple-colored spots and patches, which get pale when pressure is placed on them (purpura )
  • Skin lesions usually located on the legs, buttocks, or trunk
  • Blisters on the skin
  • Hives (urticaria ), may last longer than 24 hours
  • Open sores with dead tissue (necrotic ulcers )


Signs and tests:

The diagnosis is based on your symptoms and how the skin looks after you take a certain medicine or are exposed to a foreign substance (antigen ).

Results from an ESR test may be high. Skin biopsy shows inflammation of the blood vessels.



Treatment:

The goal of treatment is to reduce inflammation.

Your health care provider may prescribe aspirin or corticosteroids to reduce inflammation of the blood vessels. (DO NOT give aspirin to children except as advised by your health care provider.)

If possible, your doctor may tell you to stop taking the medicine that caused this condition. Do not stop taking any medicine without first talking to your doctor.



Support Groups:



Expectations (prognosis):

Allergic vasculitis usually goes away over time. On occasion, people will have repeated episodes.



Complications:
  • Permanent damage to the blood vessels or skin with scarring
  • Inflammation of the blood vessels affects the internal organs


Calling your health care provider:

Call for an appointment with your health care provider if you have symptoms of allergic vasculitis.



Prevention:

Avoid exposure to medications to which you have known allergies.



References:

Stone JH. Immune complex-mediated small vessel vasculitis. In: Firestein GS, Budd RC, Harris Jr. ED, McInnes IB, Ruddy S, eds. Kelley's Textbook of Rheumatology. 8th ed. Philadelphia, Pa: W.B. Saunders Company; 2008: chap 85.




Review Date: 5/31/2009
Reviewed By: Mark James Borigini, Associate Clinical Professor of Medicine, University of California, Irvine, Irvine, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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