EspaƱol
ABOUT US | CONTACT | VOLUNTEER | WAYS TO GIVE
MISSION & MINISTRY
Find a Physician
Decrease (-) Restore Default Increase (+)

Bone marrow aspiration
Bone marrow aspiration


Blood types
Blood types


Definition:

Secondary aplastic anemia is a failure of the bone marrow to make enough blood cells. All blood cell types are affected.



Alternative Names:

Anemia - secondary aplastic; Acquired aplastic anemia



Causes, incidence, and risk factors:

Secondary aplastic anemia is caused by injury to blood stem cells. Normal blood stem cells divide and turn into all blood cell types, mainly white blood cells, red blood cells, and platelets. When blood stem cells are injured, there is a reduction in all blood cell types.

This condition can be caused by:

  • Certain drugs
  • Chemotherapy
  • Disorders present at birth (congenital disorders)
  • Drug therapy to suppress the immune system
  • Pregnancy
  • Radiation therapy
  • Toxins such as benzene or arsenic

When the cause is unknown, it is referred to as idiopathic aplastic anemia . In about half of all cases, no cause can be found.

The disease may be acute or chronic .



Symptoms:
  • Bleeding of the gums
  • Bleeding of internal organs
  • Easy bruising
  • Fatigue
  • Frequent or severe infections
  • Nosebleeds
  • Rapid heart rate
  • Rash
  • Shortness of breath during physical activity
  • Weakness


Signs and tests:

Signs include:

Tests may include:



Treatment:

In secondary aplastic anemia, removing the cause is critical. In some cases it can lead to recovery.

Mild cases of aplastic anemia may be treated with supportive care, or may not need treatment. Blood and platelet transfusions will help correct the abnormal blood counts and relieve some symptoms in moderate cases.

Severe aplastic anemia, which causes a very low blood-cell count, is a life-threatening condition. Younger patients with a severe case of the disease will need a bone marrow transplant . Older patients, or those who do not have a matched bone marrow donor, can be treated with medications that suppress the immune system, such as antithymocyte globulin (ATG), tacrolimus, or cyclosporine.

ATG consists of antibodies made in horses or rabbits against a type of white blood cell in humans called T cells. It is used to suppress the body's immune system, allowing the bone marrow to start generating blood cells again. Other medications to suppress the immune system, such as cyclosporine, tacrolimus, and cyclophosphamide (Cytoxan) also may be used. Corticosteroids and androgens have been used as well.



Support Groups:



Expectations (prognosis):

The condition usually gets worse unless the cause is removed or the disease is treated.

Untreated severe aplastic anemia usually gets worse, eventually leading to death. Mild and moderate forms of the disease can be slower.

Bone marrow transplant has been successful in young patients. It has a long-term survival rate of approximately 80%. Older patients have a survival rate of 40 - 70% after a transplant.



Complications:
  • Bleeding in the brain
  • Death caused by bleeding, infectious complications of a bone marrow transplant, rejection of a bone marrow graft, or severe reactions to ATG
  • Infection


Calling your health care provider:

Call your health care provider if:

  • You have signs of infection, such as fever
  • You bleed for no reason
  • You are feeling extremely tired or short of breath with activity


Prevention:

Secondary aplastic anemia may be an unavoidable consequence of treatments such as chemotherapy. Avoid toxins such as benzene and arsenic, if possible.



References: Castro-Malaspina H, O'Reilly RJ. Aplastic anemia and related disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 171.


Review Date: 11/23/2008
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


About Us



Emanuel Cancer Centers 2013 Annual Report
Joint Notice of Privacy Practices
Accreditation & Quality Measures
Board of Directors
CEO's Message
Community Crisis Information
Maps & Directions
Mission & Ministry
News & Publications
Volunteer

Care & Services



Emanuel Physician Finder

Employees & Physicians



Tenet Application Process
e-MC Physician Portal
Web Mail
Employment Services
Physician Verification
Living in Turlock
Contact Us

Emanuel Medical Center
825 Delbon Avenue
Turlock, CA 95382
(209) 667-4200
Contact Us
© 2014 Emanuel Medical Center, Inc. All rights reserved
Home   |   Site Map   |   Joint Notice of Privacy Practices