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Clubbing
Clubbing


Coal workers pneumoconiosis - stage II
Coal workers pneumoconiosis - stage II


Coal workers pneumoconiosis - stage II #2
Coal workers pneumoconiosis - stage II #2


Coal workers pneumoconiosis, complicated
Coal workers pneumoconiosis, complicated


Respiratory system
Respiratory system


Definition:

Diffuse interstitial lung disease refers to a group of lung disorders in which the deep lung tissues become swollen and scarred.



Alternative Names:

Diffuse parenchymal lung disease; Alveolitis; Cryptogenic fibrosing alveolitis (CFA); Idiopathic pulmonary pneumonitis (IPP)



Causes, incidence, and risk factors:

Interstitial lung diseases (ILD) are caused by swelling and scarring of the air sacs (alveoli) and their supporting structures (the interstitium). This leads to reduced levels of oxygen in the blood.

The interstitial lung diseases can be broken down into two large groups:

  • Those that have no known cause (idiopathic ILD)
  • Those with an identifiable cause

One recent system further divides idiopathic ILD into the following three groups:

  • Idiopathic pulmonary fibrosis/usual interstitial pneumonitis (IPF/UIP)
  • Nonspecific interstitial pneumonitis (NSIP)
  • Acute interstitial pneumonitis (AIP)

There are dozens of different causes of ILD. Many occupational substances can cause ILD, including:

  • Asbestos
  • Coal dust
  • Cotton dust
  • Sand (silica) dust

People who are heavily exposed to known causes of occupational lung disease in the workplace are usually routinely screened for lung disease. This can include coal miners, sand-blasters, ship workers, and others.

Occasionally, bird keeping or bathing in hot tubs may cause some forms of ILD.

The following diseases can cause ILD:

Certain medications (such as bleomycin, amiodarone, and methotrexate) may also cause ILD.

Cigarette smoking may increase the risk of developing some forms of ILD and may cause the disease to be more severe.



Symptoms:
  • Abnormal enlargement of the base of the fingernails (clubbing )
  • Blue color of the lips, skin, or fingernails due to low blood oxygen levels (cyanosis)
  • Decreased tolerance for activity
  • Dry cough
  • Rapid breathing
  • Shortness of breath at rest or while active


Signs and tests:

The health care provider will perform a physical exam. Dry, crackling breath sounds may be heard when listening to the chest with a stethoscope. The health care provider may notice nasal flaring .

The following tests may be done:



Treatment:

The treatment depends on the cause of the disease. Most often, anti-inflammatory drugs, such as corticosteroids or immunosuppressing drugs, are prescribed.

If there is no specific treatment for the condition, therapy is aimed at making the person more comfortable and supporting lung function. Those with low blood oxygen levels will receive oxygen. Lung rehabilitation can help people with advanced ILD.

Some patients with advanced ILD may need a lung transplant.



Support Groups:

For additional information and resources, see lung disease support group .



Expectations (prognosis):

Chances of recovery or the disease getting worse depend on the cause, and how severe the disease was when it was first diagnosed.



Complications:

Calling your health care provider:

Call your health care provider if you have shortness of breath at rest that lasts for any period of time.



Prevention:

Avoid exposure to substances known to cause lung disease .

Quitting smoking can prevent ILD from getting worse.



References: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders; 2008.


Review Date: 1/18/2008
Reviewed By: Andrew Schriber, MD, FCCP, Specialist in Pulmonary, Critical Care, and Sleep Medicine, Virtua Memorial Hospital, Mount Holly, New Jersey. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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